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357158-20-4

357158-20-4 structure

357158-20-4 structure

Name: BVFP
Chemical Name: BVFP
CAS Number: 357158-20-4
Molecular Formula: C₁₃H₈BrF₃N₂O
Molecular Weight: 345.11
Catalog: Signaling Pathways GPCR/G Protein Neurotensin Receptor
Create Date: 2023-09-30 16:43:08
Modify Date: 2025-08-21 07:08:11
BVFP binds to the PGRN588–593 peptide with a Kd of 20 μM. BVFP can disrupt PGRN-SORT1 binding. BVFP also inhibits SORT1-mediated rPGRN endocytosis[1].

Name	BVFP

Description	BVFP binds to the PGRN588–593 peptide with a Kd of 20 μM. BVFP can disrupt PGRN-SORT1 binding. BVFP also inhibits SORT1-mediated rPGRN endocytosis[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neurotensin Receptor Research Areas >> Neurological Disease
References	[1]. Lee WC, et al. Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency. Hum Mol Genet. 2014 Mar 15;23(6):1467-78.

Molecular Formula	C₁₃H₈BrF₃N₂O
Molecular Weight	345.11

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