1021920-32-0

1021920-32-0 structure

Name: CC214-1
Chemical Name: CC214-1
CAS Number: 1021920-32-0
Molecular Formula: C₂₀H₂₁N₇O₂
Molecular Weight: 391.43
Catalog: Signaling Pathways PI3K/Akt/mTOR mTOR
Create Date: 2023-09-24 08:15:38
Modify Date: 2025-09-26 08:15:50
CC214-1 is a potentially efficacious mTOR inhibitor that induces autophagy [1],with an IC50 is 0.002 μM. CC214-1 proved to be useful as an in vitro tool compound for the exploration of mTOR kinase biology. CC214-1 can be used for Glioblastoma study[2].

Name	CC214-1

Description	CC214-1 is a potentially efficacious mTOR inhibitor that induces autophagy [1],with an IC50 is 0.002 μM. CC214-1 proved to be useful as an in vitro tool compound for the exploration of mTOR kinase biology. CC214-1 can be used for Glioblastoma study[2].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Research Areas >> Cancer
Target	mTOR:0.002 μM (IC50)
References	[1]. Gini B, et al. The mTOR kinase inhibitors, CC214-1 and CC214-2, preferentially block the growth of EGFRvIII-activated glioblastomas. Clin Cancer Res. 2013 Oct 15;19(20):5722-32. [2]. Mortensen DS, et al. Use of core modification in the discovery of CC214-2, an orally available, selective inhibitor of mTOR kinase. Bioorg Med Chem Lett. 2013 Mar 15;23(6):1588-91. [3]. Herrero-Sánchez MC, et al. Effect of mTORC1/mTORC2 inhibition on T cell function: potential role in graft-versus-host disease control. Br J Haematol. 2016 Jun;173(5):754-68.

Molecular Formula	C₂₀H₂₁N₇O₂
Molecular Weight	391.43