381725-58-2

381725-58-2 structure

Name: Conopeptide rho-TIA
Chemical Name: Conopeptide rho-TIA
CAS Number: 381725-58-2
Molecular Formula: C₁₀₅H₁₆₀N₃₆O₂₁S₄
Molecular Weight: 2390.88
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2023-11-26 11:31:39
Modify Date: 2025-08-27 11:08:57
Conopeptide rho-TIA is a peptide derived from the venom contained in the predatory sea snail Conus tulipa, has highly selective and noncompetitive inhibitor at human α1B-Adrenergic Receptor. Conopeptide rho-TIA acts a competitive inhibitor at human α1A-Adrenergic Receptor and α1D-Adrenergic Receptor. Conopeptide rho-TIA binds to each subtype and may provide useful information for the development of novel α1-Adrenergic Receptor subtype-selective drugs[1].

Name	Conopeptide rho-TIA

Description	Conopeptide rho-TIA is a peptide derived from the venom contained in the predatory sea snail Conus tulipa, has highly selective and noncompetitive inhibitor at human α1B-Adrenergic Receptor. Conopeptide rho-TIA acts a competitive inhibitor at human α1A-Adrenergic Receptor and α1D-Adrenergic Receptor. Conopeptide rho-TIA binds to each subtype and may provide useful information for the development of novel α1-Adrenergic Receptor subtype-selective drugs[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Target	α1B Adrenergic Receptor α1A Adrenergic Receptor α1D Adrenergic Receptor
References	[1]. Chen Z, et al. Subtype-selective noncompetitive or competitive inhibition of human alpha1-adrenergic receptors by rho-TIA. J Biol Chem. 2004 Aug 20;279(34):35326-33. [2]. Sharpe IA, et al. Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA. J Biol Chem. 2003 Sep 5;278(36):34451-7.

Molecular Formula	C₁₀₅H₁₆₀N₃₆O₂₁S₄
Molecular Weight	2390.88