2169302-75-2

2169302-75-2 structure

Name: ERK1/2 inhibitor 9
Chemical Name: ERK1/2 inhibitor 9
CAS Number: 2169302-75-2
Molecular Formula: C₃₁H₃₂ClN₇O₃
Molecular Weight: 586.08
Catalog: Signaling Pathways MAPK/ERK Pathway ERK
Create Date: 2023-10-01 02:48:03
Modify Date: 2024-01-16 22:11:37
ERK1/2 inhibitor 9 (Probe 1) is a covalent ERK1/2 inhibitor. ERK1/2 inhibitor 9 shows sub-micromolar activity in cells (A375 GI50=0.47 μM). ERK1/2 inhibitor 9 causes the downregulation of phospho-ERK1/2. ERK1/2 inhibitor 9 tagged trans-cyclo-octene (TCO) and Tz-Thalidomide (tetrazine tagged Thalidomide) can form the corresponding ERK-CLIPTAC to elicit degradation of ERK1/2[1].

Name	ERK1/2 inhibitor 9

Description	ERK1/2 inhibitor 9 (Probe 1) is a covalent ERK1/2 inhibitor. ERK1/2 inhibitor 9 shows sub-micromolar activity in cells (A375 GI50=0.47 μM). ERK1/2 inhibitor 9 causes the downregulation of phospho-ERK1/2. ERK1/2 inhibitor 9 tagged trans-cyclo-octene (TCO) and Tz-Thalidomide (tetrazine tagged Thalidomide) can form the corresponding ERK-CLIPTAC to elicit degradation of ERK1/2[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	ERK1 ERK2
References	[1]. Honorine Lebraud, et al. Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras. ACS Cent Sci. 2016 Dec 28;2(12):927-934.

Molecular Formula	C₃₁H₃₂ClN₇O₃
Molecular Weight	586.08