2271035-37-9

2271035-37-9 structure

Name: FC-11
Chemical Name: FC-11
CAS Number: 2271035-37-9
Molecular Formula: C₄₁H₄₂F₃N₁₃O₉S
Molecular Weight: 949.91
Catalog: Signaling Pathways PROTAC PROTAC
Create Date: 2023-09-29 20:27:01
Modify Date: 2024-01-15 11:54:32
FC-11 is a PROTAC FAK degrader (DC90: 1 nM) . FC-11 contains CRBN ligand Pomalidomide (HY-10984), linker and FAK ligand PF562271 (HY-10459). FC-11 degrades FAK in various cells, with DC50s of 310 pM in TM3, 80 pM in PA1, 330 pM in MDA-MB-436, 370 pM in LNCaP, and 40 pM in Ramos cells[1].

Name	FC-11

Description	FC-11 is a PROTAC FAK degrader (DC90: 1 nM) . FC-11 contains CRBN ligand Pomalidomide (HY-10984), linker and FAK ligand PF562271 (HY-10459). FC-11 degrades FAK in various cells, with DC50s of 310 pM in TM3, 80 pM in PA1, 330 pM in MDA-MB-436, 370 pM in LNCaP, and 40 pM in Ramos cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FAK Signaling Pathways >> PROTAC >> PROTAC
References	[1]. Gao H, et al. Design, Synthesis, and Evaluation of Highly Potent FAK-Targeting PROTACs. ACS Med Chem Lett. 2019 Oct 22;11(10):1855-1862. Gao H, Wu Y, Sun Y, Yang Y, Zhou G, Rao Y. Design, Synthesis, and Evaluation of Highly Potent FAK-Targeting PROTACs. ACS Med Chem Lett. 2019 Oct 22;11(10):1855-1862.

Molecular Formula	C₄₁H₄₂F₃N₁₃O₉S
Molecular Weight	949.91