FC-11
Modify Date: 2025-09-22 18:37:56
FC-11 structure
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Common Name | FC-11 | ||
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| CAS Number | 2271035-37-9 | Molecular Weight | 949.91 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C41H42F3N13O9S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of FC-11FC-11 is a PROTAC FAK degrader (DC90: 1 nM) . FC-11 contains CRBN ligand Pomalidomide (HY-10984), linker and FAK ligand PF562271 (HY-10459). FC-11 degrades FAK in various cells, with DC50s of 310 pM in TM3, 80 pM in PA1, 330 pM in MDA-MB-436, 370 pM in LNCaP, and 40 pM in Ramos cells[1]. |
| Name | FC-11 |
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| Description | FC-11 is a PROTAC FAK degrader (DC90: 1 nM) . FC-11 contains CRBN ligand Pomalidomide (HY-10984), linker and FAK ligand PF562271 (HY-10459). FC-11 degrades FAK in various cells, with DC50s of 310 pM in TM3, 80 pM in PA1, 330 pM in MDA-MB-436, 370 pM in LNCaP, and 40 pM in Ramos cells[1]. |
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| Related Catalog | |
| References |
| Molecular Formula | C41H42F3N13O9S |
|---|---|
| Molecular Weight | 949.91 |
| InChIKey | RZKZQCHSKWKOAJ-UHFFFAOYSA-N |
| SMILES | CN(c1ncccc1CNc1nc(Nc2ccc(NC(=O)c3cn(CCOCCOCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)nn3)cc2)ncc1C(F)(F)F)S(C)(=O)=O |