1422456-47-0

1422456-47-0 structure
1422456-47-0 structure
  • Name: FD1024
  • Chemical Name: FD1024
  • CAS Number: 1422456-47-0
  • Molecular Formula: C21H20F2N4O2S
  • Molecular Weight: 430.47
  • Catalog: Signaling Pathways JAK/STAT Signaling Pim
  • Create Date: 2023-09-17 12:29:25
  • Modify Date: 2025-08-24 14:47:35
  • FD1024 is PIM inhibitor (IC50s: 1.96, 38.9, 4.17 nM for PIM1, 2, 3). FD1024 can be used for research of acute myeloid leukemia. FD1024 has strong antiproliferative activity against the tested AML cell lines, with 0.16 μM, 0.12 μM, 1.05 μM, 1.39μM for EOL-1, MV-4-11, KG-1, MOLM-16 cells. FD1024 also has antitumor efficacy in mice[1].

Name FD1024
Description FD1024 is PIM inhibitor (IC50s: 1.96, 38.9, 4.17 nM for PIM1, 2, 3). FD1024 can be used for research of acute myeloid leukemia. FD1024 has strong antiproliferative activity against the tested AML cell lines, with 0.16 μM, 0.12 μM, 1.05 μM, 1.39μM for EOL-1, MV-4-11, KG-1, MOLM-16 cells. FD1024 also has antitumor efficacy in mice[1].
Related Catalog
Target

1.96, 38.9, 4.17 nM for PIM1, 2, 3[1]

References

[1]. Xiang R, et al. Discovery of a high potent PIM kinase inhibitor for acute myeloid leukemia based on N-pyridinyl amide scaffold by optimizing the fragments toward to Lys67 and Asp128/Glu171. Eur J Med Chem. 2023 Sep 5;257:115514.  

Molecular Formula C21H20F2N4O2S
Molecular Weight 430.47
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