2230974-62-4

2230974-62-4 structure

Name: Irpagratinib
Chemical Name: Irpagratinib
CAS Number: 2230974-62-4
Molecular Formula: C₂₈H₃₂F₂N₆O₅
Molecular Weight: 570.59
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK FGFR
Create Date: 2023-09-29 13:14:49
Modify Date: 2024-01-11 12:39:34
Irpagratinib (ABSK011) is an orally active inhibitor of fibroblast growth factor receptor (FGFR) tyrosine kinase, targeting to FGFR4 (IC50<10 nM). Irpagratinib inhibits the auto-phosphorylation of FGFR4 and blocks signal transduction from FGFR4 to downstream pathway activation. Irpagratinib exhibits high exposure in PK study in mouse, rat and dog, and also shows antineoplastic/anti-tumor activity in subcutaneous xenograft tumor models[1].

Name	Irpagratinib

Description	Irpagratinib (ABSK011) is an orally active inhibitor of fibroblast growth factor receptor (FGFR) tyrosine kinase, targeting to FGFR4 (IC50<10 nM). Irpagratinib inhibits the auto-phosphorylation of FGFR4 and blocks signal transduction from FGFR4 to downstream pathway activation. Irpagratinib exhibits high exposure in PK study in mouse, rat and dog, and also shows antineoplastic/anti-tumor activity in subcutaneous xenograft tumor models[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR
Target	FGFR4[1]
References	[1]. Chen Z. Abstract LB-272: Discovery and characterization of a novel FGFR4 Inhibitor for the treatment of hepatocellular carcinoma[J]. Cancer Research, 2018, 78(13_Supplement): LB-272-LB-272.

Molecular Formula	C₂₈H₃₂F₂N₆O₅
Molecular Weight	570.59