2374772-60-6

2374772-60-6 structure

2374772-60-6 structure

Name: J-1048
Chemical Name: J-1048
CAS Number: 2374772-60-6
Molecular Formula: C₂₃H₁₇FN₆S₂
Molecular Weight: 460.55
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK ALK
Create Date: 2023-09-22 20:01:56
Modify Date: 2024-01-17 15:54:50
J-1048 is an activin receptor-like kinase 5 (ALK5) inhibitor. J-1048 can inhibit TAA-induced liver fibrosis in mice by explicitly blocking the TGF-β/Smad signaling pathway[1].

Name	J-1048

Description	J-1048 is an activin receptor-like kinase 5 (ALK5) inhibitor. J-1048 can inhibit TAA-induced liver fibrosis in mice by explicitly blocking the TGF-β/Smad signaling pathway[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK
References	[1]. Yang HX, et al. Synthesis of and anti-fibrotic effect of pyrazole derivative J-1048: Inhibition of ALK5 as a novel approach to liver fibrosis targeting inflammation. Bioorg Chem. 2023 Oct;139:106723.

Molecular Formula	C₂₃H₁₇FN₆S₂
Molecular Weight	460.55