J-1048

Modify Date: 2024-01-17 15:54:50

J-1048 Structure
J-1048 structure
Common Name J-1048
CAS Number 2374772-60-6 Molecular Weight 460.55
Density N/A Boiling Point N/A
Molecular Formula C23H17FN6S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of J-1048


J-1048 is an activin receptor-like kinase 5 (ALK5) inhibitor. J-1048 can inhibit TAA-induced liver fibrosis in mice by explicitly blocking the TGF-β/Smad signaling pathway[1].

 Names

Name J-1048

 J-1048 Biological Activity

Description J-1048 is an activin receptor-like kinase 5 (ALK5) inhibitor. J-1048 can inhibit TAA-induced liver fibrosis in mice by explicitly blocking the TGF-β/Smad signaling pathway[1].
Related Catalog
References

[1]. Yang HX, et al. Synthesis of and anti-fibrotic effect of pyrazole derivative J-1048: Inhibition of ALK5 as a novel approach to liver fibrosis targeting inflammation. Bioorg Chem. 2023 Oct;139:106723.  

 Chemical & Physical Properties

Molecular Formula C23H17FN6S2
Molecular Weight 460.55