J-1048

Modify Date: 2025-11-27 15:42:03

J-1048 structure	Common Name	J-1048
	CAS Number	2374772-60-6	Molecular Weight	460.55
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₁₇FN₆S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of J-1048

J-1048 is an activin receptor-like kinase 5 (ALK5) inhibitor. J-1048 can inhibit TAA-induced liver fibrosis in mice by explicitly blocking the TGF-β/Smad signaling pathway[1].

Name	J-1048

Description	J-1048 is an activin receptor-like kinase 5 (ALK5) inhibitor. J-1048 can inhibit TAA-induced liver fibrosis in mice by explicitly blocking the TGF-β/Smad signaling pathway[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK
References	[1]. Yang HX, et al. Synthesis of and anti-fibrotic effect of pyrazole derivative J-1048: Inhibition of ALK5 as a novel approach to liver fibrosis targeting inflammation. Bioorg Chem. 2023 Oct;139:106723.

Molecular Formula	C₂₃H₁₇FN₆S₂
Molecular Weight	460.55
InChIKey	TVWMUKRZUMLJMU-UHFFFAOYSA-N
SMILES	Cc1cccc(-c2nn(CC(=S)Nc3cccc(F)c3)cc2-c2ccc3nsnc3c2)n1

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: J-1048
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: J-1048
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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J-1048

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.