2566715-91-9

2566715-91-9 structure

Name: KSK68
Chemical Name: KSK68
CAS Number: 2566715-91-9
Molecular Formula: C₂₃H₂₈N₂O₂
Molecular Weight: 364.48
Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
Create Date: 2023-10-02 18:12:27
Modify Date: 2024-01-28 10:51:42
KSK68 is a high-affinity dual sigma-1 and histamine H3 receptor antagonist, with Kis of 7.7, 3.6, 22.4 nM for H3 receptor, sigma-1, sigma-2 receptor respectively. KSK68 has negligible affinity at the other histamine receptor subtypes. KSK68 can be used for research of nociceptive and neuropathic pain[1].

Name	KSK68

Description	KSK68 is a high-affinity dual sigma-1 and histamine H3 receptor antagonist, with Kis of 7.7, 3.6, 22.4 nM for H3 receptor, sigma-1, sigma-2 receptor respectively. KSK68 has negligible affinity at the other histamine receptor subtypes. KSK68 can be used for research of nociceptive and neuropathic pain[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Sigma Receptor Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	7.7 nM, 3.6 nM、22.4 nM (H3 receptor, sigma-1, sigma-2 receptor)[1]
References	[1]. Szczepańska K, et al. Dual Piperidine-Based Histamine H3 and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain. J Med Chem. 2023 Jul 27;66(14):9658-9683.

Molecular Formula	C₂₃H₂₈N₂O₂
Molecular Weight	364.48