461450-30-6
461450-30-6 structure
- Name: MRK-898
- Chemical Name: MRK-898
- CAS Number: 461450-30-6
- Molecular Formula: C20H9F5N4
- Molecular Weight: 400.30
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
- Create Date: 2023-11-14 14:12:52
- Modify Date: 2024-02-24 15:52:59
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MRK-898 is an orally active GABA(A) receptor modulator. MRK-898 binds to α1, α2, α3 or α5 subunit of GABA(A) receptor with Ki values of 1.2 nM, 1.0 nM, 0.73 nM, and 0.50 nM, respectively. However, α1-containing GABA(A) receptors are identified as the "sedative" and α2- and/or α3-containing receptors as the "anxiolytic" subtype(s)[1].
| Name | MRK-898 |
|---|
| Description | MRK-898 is an orally active GABA(A) receptor modulator. MRK-898 binds to α1, α2, α3 or α5 subunit of GABA(A) receptor with Ki values of 1.2 nM, 1.0 nM, 0.73 nM, and 0.50 nM, respectively. However, α1-containing GABA(A) receptors are identified as the "sedative" and α2- and/or α3-containing receptors as the "anxiolytic" subtype(s)[1]. |
|---|---|
| Related Catalog | |
| Target |
α1 GABA(A) receptor:1.2 nM (Ki) α2 GABA(A) receptor:1.0 nM (Ki) α3 GABA(A) receptor:0.73 nM (Ki) α5 GABA(A) receptor:0.50 nM (Ki) |
| References |
| Molecular Formula | C20H9F5N4 |
|---|---|
| Molecular Weight | 400.30 |