MRK-898
Modify Date: 2025-09-01 00:25:34
MRK-898 structure
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Common Name | MRK-898 | ||
|---|---|---|---|---|
| CAS Number | 461450-30-6 | Molecular Weight | 400.30 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H9F5N4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MRK-898MRK-898 is an orally active GABA(A) receptor modulator. MRK-898 binds to α1, α2, α3 or α5 subunit of GABA(A) receptor with Ki values of 1.2 nM, 1.0 nM, 0.73 nM, and 0.50 nM, respectively. However, α1-containing GABA(A) receptors are identified as the "sedative" and α2- and/or α3-containing receptors as the "anxiolytic" subtype(s)[1]. |
| Name | MRK-898 |
|---|
| Description | MRK-898 is an orally active GABA(A) receptor modulator. MRK-898 binds to α1, α2, α3 or α5 subunit of GABA(A) receptor with Ki values of 1.2 nM, 1.0 nM, 0.73 nM, and 0.50 nM, respectively. However, α1-containing GABA(A) receptors are identified as the "sedative" and α2- and/or α3-containing receptors as the "anxiolytic" subtype(s)[1]. |
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| Related Catalog | |
| Target |
α1 GABA(A) receptor:1.2 nM (Ki) α2 GABA(A) receptor:1.0 nM (Ki) α3 GABA(A) receptor:0.73 nM (Ki) α5 GABA(A) receptor:0.50 nM (Ki) |
| References |
| Molecular Formula | C20H9F5N4 |
|---|---|
| Molecular Weight | 400.30 |
| InChIKey | XXRKXVKJMSIZSM-UHFFFAOYSA-N |
| SMILES | N#Cc1cc(F)ccc1-c1cc(-c2cnc3nc(C(F)(F)F)ccn23)ccc1F |