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2146132-73-0

2146132-73-0 structure
2146132-73-0 structure
  • Name: OATD-02
  • Chemical Name: OATD-02
  • CAS Number: 2146132-73-0
  • Molecular Formula: C12H25BN2O4
  • Molecular Weight: 272.15
  • Catalog: Research Areas Cancer
  • Create Date: 2023-09-30 10:59:08
  • Modify Date: 2025-08-25 16:07:15
  • OATD-02 is an orally active, competitive, reversible, noncovalent dual inhibitor of Arginase1 and 2. OATD-02 is a slow offset inhibitor, blocking intracellular arginases with IC50s of 20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), and 28 nM (rARG1), respectively. OATD-02 abolishes tumor immunosuppression induced by both arginases. OATD-02 can be used for melanoma study[1].

Name OATD-02
Description OATD-02 is an orally active, competitive, reversible, noncovalent dual inhibitor of Arginase1 and 2. OATD-02 is a slow offset inhibitor, blocking intracellular arginases with IC50s of 20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), and 28 nM (rARG1), respectively. OATD-02 abolishes tumor immunosuppression induced by both arginases. OATD-02 can be used for melanoma study[1].
Related Catalog
Target

20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), 28 nM (rARG1)

References

[1]. Borek B, et al. Arginase 1/2 Inhibitor OATD-02: From Discovery to First-in-man Setup in Cancer Immunotherapy. Mol Cancer Ther. 2023;22(7):807-817.  

Molecular Formula C12H25BN2O4
Molecular Weight 272.15
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