2146132-73-0
2146132-73-0 structure
- Name: OATD-02
- Chemical Name: OATD-02
- CAS Number: 2146132-73-0
- Molecular Formula: C12H25BN2O4
- Molecular Weight: 272.15
- Catalog: Research Areas Cancer
- Create Date: 2023-09-30 10:59:08
- Modify Date: 2024-01-24 16:35:05
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OATD-02 is an orally active, competitive, reversible, noncovalent dual inhibitor of Arginase1 and 2. OATD-02 is a slow offset inhibitor, blocking intracellular arginases with IC50s of 20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), and 28 nM (rARG1), respectively. OATD-02 abolishes tumor immunosuppression induced by both arginases. OATD-02 can be used for melanoma study[1].
| Name | OATD-02 |
|---|
| Description | OATD-02 is an orally active, competitive, reversible, noncovalent dual inhibitor of Arginase1 and 2. OATD-02 is a slow offset inhibitor, blocking intracellular arginases with IC50s of 20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), and 28 nM (rARG1), respectively. OATD-02 abolishes tumor immunosuppression induced by both arginases. OATD-02 can be used for melanoma study[1]. |
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| Related Catalog | |
| Target |
20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), 28 nM (rARG1) |
| References |
| Molecular Formula | C12H25BN2O4 |
|---|---|
| Molecular Weight | 272.15 |