OATD-02
Modify Date: 2025-08-25 16:07:15
OATD-02 structure
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Common Name | OATD-02 | ||
|---|---|---|---|---|
| CAS Number | 2146132-73-0 | Molecular Weight | 272.15 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H25BN2O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of OATD-02OATD-02 is an orally active, competitive, reversible, noncovalent dual inhibitor of Arginase1 and 2. OATD-02 is a slow offset inhibitor, blocking intracellular arginases with IC50s of 20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), and 28 nM (rARG1), respectively. OATD-02 abolishes tumor immunosuppression induced by both arginases. OATD-02 can be used for melanoma study[1]. |
| Name | OATD-02 |
|---|
| Description | OATD-02 is an orally active, competitive, reversible, noncovalent dual inhibitor of Arginase1 and 2. OATD-02 is a slow offset inhibitor, blocking intracellular arginases with IC50s of 20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), and 28 nM (rARG1), respectively. OATD-02 abolishes tumor immunosuppression induced by both arginases. OATD-02 can be used for melanoma study[1]. |
|---|---|
| Related Catalog | |
| Target |
20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), 28 nM (rARG1) |
| References |
| Molecular Formula | C12H25BN2O4 |
|---|---|
| Molecular Weight | 272.15 |
| InChIKey | NZNAXQBYXLSQHO-JBLDHEPKSA-N |
| SMILES | CN(C)CC1CCC(CCB(O)O)CC1(N)C(=O)O |