2632874-49-6
2632874-49-6 structure
- Name: P-Gb-In-1
- Chemical Name: P-gb-IN-1
- CAS Number: 2632874-49-6
- Molecular Formula: C30H28N2O6
- Molecular Weight: 512.55
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel P-glycoprotein
- Create Date: 2023-09-18 17:19:04
- Modify Date: 2026-06-25 17:42:22
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P-gb-IN-1 (compound Ⅲ-8), a 2,5-disubstituted furan derivative, is a highly effective, broadspectrum P-glycoprotein (P-gp) inhibitor. P-gb-IN-1 displayed the reversal activity by inhibiting P-gp efflux. P-gb-IN-1 has a potent affinity to P-gp by forming H-bond interactions with residues Asn 721 and Met 986. P-gb-IN-1 possesses broad-spectrum reversal activity and low toxicity in MCF-7/ADR cells[1].
| Name | P-gb-IN-1 |
|---|---|
| Synonyms |
Benzamide, N-[4-[5-[(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)carbonyl]-2-furanyl]phenyl]-4-methoxy
N-(4-(5-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)furan-2-yl)phenyl)-4-methoxybenzamide |
| Description | P-gb-IN-1 (compound Ⅲ-8), a 2,5-disubstituted furan derivative, is a highly effective, broadspectrum P-glycoprotein (P-gp) inhibitor. P-gb-IN-1 displayed the reversal activity by inhibiting P-gp efflux. P-gb-IN-1 has a potent affinity to P-gp by forming H-bond interactions with residues Asn 721 and Met 986. P-gb-IN-1 possesses broad-spectrum reversal activity and low toxicity in MCF-7/ADR cells[1]. |
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| Related Catalog | |
| References |
| Molecular Formula | C30H28N2O6 |
|---|---|
| Molecular Weight | 512.55 |