P-Gb-In-1
Modify Date: 2024-01-08 11:49:22
P-Gb-In-1 structure
|
Common Name | P-Gb-In-1 | ||
|---|---|---|---|---|
| CAS Number | 2632874-49-6 | Molecular Weight | 512.55 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H28N2O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of P-Gb-In-1P-gb-IN-1 (compound Ⅲ-8), a 2,5-disubstituted furan derivative, is a highly effective, broadspectrum P-glycoprotein (P-gp) inhibitor. P-gb-IN-1 displayed the reversal activity by inhibiting P-gp efflux. P-gb-IN-1 has a potent affinity to P-gp by forming H-bond interactions with residues Asn 721 and Met 986. P-gb-IN-1 possesses broad-spectrum reversal activity and low toxicity in MCF-7/ADR cells[1]. |
| Name | P-gb-IN-1 |
|---|
| Description | P-gb-IN-1 (compound Ⅲ-8), a 2,5-disubstituted furan derivative, is a highly effective, broadspectrum P-glycoprotein (P-gp) inhibitor. P-gb-IN-1 displayed the reversal activity by inhibiting P-gp efflux. P-gb-IN-1 has a potent affinity to P-gp by forming H-bond interactions with residues Asn 721 and Met 986. P-gb-IN-1 possesses broad-spectrum reversal activity and low toxicity in MCF-7/ADR cells[1]. |
|---|---|
| Related Catalog | |
| References |
| Molecular Formula | C30H28N2O6 |
|---|---|
| Molecular Weight | 512.55 |
| InChIKey | FAYQCAXJNWNFQJ-UHFFFAOYSA-N |
| SMILES | COc1ccc(C(=O)Nc2ccc(-c3ccc(C(=O)N4CCc5cc(OC)c(OC)cc5C4)o3)cc2)cc1 |