2642327-52-2

2642327-52-2 structure
2642327-52-2 structure
  • Name: PAD4-IN-2
  • Chemical Name: PAD4-IN-2
  • CAS Number: 2642327-52-2
  • Molecular Formula: C20H23BClN7O6
  • Molecular Weight: 503.70
  • Catalog: Research Areas Cancer
  • Create Date: 2023-10-04 12:12:14
  • Modify Date: 2024-01-13 10:38:09
  • PAD4-IN-2 (compound 5i) is a PAD4 inhibitor (IC50=1.94 μM). PAD4-IN-2 inhibits tumor growth in mice by specifically inhibiting the PAD4-H3cit-NETs pathway in neutrophils[1].

Name PAD4-IN-2
Description PAD4-IN-2 (compound 5i) is a PAD4 inhibitor (IC50=1.94 μM). PAD4-IN-2 inhibits tumor growth in mice by specifically inhibiting the PAD4-H3cit-NETs pathway in neutrophils[1].
Related Catalog
Target

IC50: 1.94 μM (PAD4)[1].

References

[1]. Zhu D, et al. Highly-tumor-targeted PAD4 inhibitors with PBA modification inhibit tumors in vivo by specifically inhibiting the PAD4-H3cit-NETs pathway in neutrophils. Eur J Med Chem. 2023 Oct 5;258:115619.  

Molecular Formula C20H23BClN7O6
Molecular Weight 503.70