2417296-82-1

2417296-82-1 structure

Name: PROTAC BRAF-V600E degrader-2
Chemical Name: PROTAC BRAF-V600E degrader-2
CAS Number: 2417296-82-1
Molecular Formula: C₄₂H₃₉F₂N₇O₈S
Molecular Weight: 839.86
Catalog: Signaling Pathways MAPK/ERK Pathway Raf
Create Date: 2023-10-12 23:49:58
Modify Date: 2024-01-12 09:42:03
PROTAC BRAF-V600E degrader-2 (compound 12) is a potent BRAF-V600E degrader with Kds of 14.4 nM and 9.5 nM for BRAF and BRAF-V600E, respectively. PROTAC BRAF-V600E degrader-2 selectively degraded the kinase domain of BRAF-V600E but not the wild-type BRAF. PROTAC BRAF-V600E degrader-2 inhibits melanoma cell growth[1].

Name	PROTAC BRAF-V600E degrader-2

Description	PROTAC BRAF-V600E degrader-2 (compound 12) is a potent BRAF-V600E degrader with Kds of 14.4 nM and 9.5 nM for BRAF and BRAF-V600E, respectively. PROTAC BRAF-V600E degrader-2 selectively degraded the kinase domain of BRAF-V600E but not the wild-type BRAF. PROTAC BRAF-V600E degrader-2 inhibits melanoma cell growth[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> Raf Signaling Pathways >> PROTAC >> PROTAC
Target	BRAF-V600E:9.5 nM (Kd) Braf:14.4 nM (Kd) Cereblon
References	[1]. Xiao-Ran Han, et al. Discovery of Selective Small Molecule Degraders of BRAF-V600E. J Med Chem. 2020 Apr 23;63(8):4069-4080.

Molecular Formula	C₄₂H₃₉F₂N₇O₈S
Molecular Weight	839.86