PROTAC BRAF-V600E degrader-2

Modify Date: 2024-01-12 09:42:03

PROTAC BRAF-V600E degrader-2 Structure
PROTAC BRAF-V600E degrader-2 structure
 Common Name PROTAC BRAF-V600E degrader-2
CAS Number 2417296-82-1 Molecular Weight 839.86
Density N/A Boiling Point N/A
Molecular Formula C42H39F2N7O8S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PROTAC BRAF-V600E degrader-2


PROTAC BRAF-V600E degrader-2 (compound 12) is a potent BRAF-V600E degrader with Kds of 14.4 nM and 9.5 nM for BRAF and BRAF-V600E, respectively. PROTAC BRAF-V600E degrader-2 selectively degraded the kinase domain of BRAF-V600E but not the wild-type BRAF. PROTAC BRAF-V600E degrader-2 inhibits melanoma cell growth[1].

 Names

Name PROTAC BRAF-V600E degrader-2

 PROTAC BRAF-V600E degrader-2 Biological Activity

Description PROTAC BRAF-V600E degrader-2 (compound 12) is a potent BRAF-V600E degrader with Kds of 14.4 nM and 9.5 nM for BRAF and BRAF-V600E, respectively. PROTAC BRAF-V600E degrader-2 selectively degraded the kinase domain of BRAF-V600E but not the wild-type BRAF. PROTAC BRAF-V600E degrader-2 inhibits melanoma cell growth[1].
Related Catalog
Target

BRAF-V600E:9.5 nM (Kd)

Braf:14.4 nM (Kd)

Cereblon

References

[1]. Xiao-Ran Han, et al. Discovery of Selective Small Molecule Degraders of BRAF-V600E. J Med Chem. 2020 Apr 23;63(8):4069-4080.  

 Chemical & Physical Properties

Molecular Formula C42H39F2N7O8S
Molecular Weight 839.86
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Chemsrc provides PROTAC BRAF-V600E degrader-2(CAS#:2417296-82-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of PROTAC BRAF-V600E degrader-2 are included as well.>> amp version: PROTAC BRAF-V600E degrader-2

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