433224-29-4

433224-29-4 structure

Name: TIE-2/VEGFR-2 kinase-IN-4
Chemical Name: TIE-2/VEGFR-2 kinase-IN-4
CAS Number: 433224-29-4
Molecular Formula: C₂₆H₁₇F₄N₅O₄
Molecular Weight: 539.44
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK VEGFR
Create Date: 2023-10-03 22:26:30
Modify Date: 2025-08-20 23:00:20
TIE-2/VEGFR-2 kinase-IN-4, benzimidazole, is a potent TIE-2 and VEGFR-2 tyrosine kinase receptors inhibitors with IC50 values of 5.2 nM and 5.1 nM, respectively. TIE-2/VEGFR-2 kinase-IN-4 can be used for the research of angiogenesis[1].

Name	TIE-2/VEGFR-2 kinase-IN-4

Description	TIE-2/VEGFR-2 kinase-IN-4, benzimidazole, is a potent TIE-2 and VEGFR-2 tyrosine kinase receptors inhibitors with IC50 values of 5.2 nM and 5.1 nM, respectively. TIE-2/VEGFR-2 kinase-IN-4 can be used for the research of angiogenesis[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	Tie2:5.2 mM (IC50) VEGFR-2:5.1 nM (IC50)
References	[1]. Hasegawa M, et al. Discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors. J Med Chem. 2007 Sep 6;50(18):4453-70.

Molecular Formula	C₂₆H₁₇F₄N₅O₄
Molecular Weight	539.44