20189-11-1

20189-11-1 structure

Name: 2-Methoxy(O-2H5)phenol
Chemical Name: 2-methoxyphenol-3,4,5,6-d4,od
CAS Number: 20189-11-1
Molecular Formula: C₇H₃D₅O₂
Molecular Weight: 129.168
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2018-04-08 08:00:00
Modify Date: 2024-01-24 09:23:04
Guaiacol-d4-1 is the deuterium labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

Name	2-methoxyphenol-3,4,5,6-d4,od
Synonyms	2-Methoxy(O-H)phenol Phenol-2,3,4,5-d-d, 6-methoxy-

Description	Guaiacol-d4-1 is the deuterium labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Murakami Y, et al. Re-evaluation of cyclooxygenase-2-inhibiting activity of vanillin and Guaiacol in macrophages stimulated with lipopolysaccharide. Anticancer Res. 2007 Mar-Apr;27(2):801-7.