2093408-03-6
2093408-03-6 structure
- Name: AY 254
- Chemical Name: AY 254
- CAS Number: 2093408-03-6
- Molecular Formula: C30H49N9O6
- Molecular Weight: 631.779
- Catalog: Signaling Pathways GPCR/G Protein Protease-Activated Receptor (PAR)
- Create Date: 2023-12-22 13:28:02
- Modify Date: 2024-01-14 10:10:01
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AY 254 is a potent PAR2 biased agonist. Selectively activates ERK1/2 signaling (EC50= 2 nM for ERK1/2 phosphorylation versus 80 nM for Ca2+release). Reduces cytoKi ne-induced caspase 3/8 activation, promotes scratch-wound healing, and induces IL-8 secretion, in human colorectal cancer (HT29) cellsin vitro.
| Name | AY 254 |
|---|
| Description | AY 254 is a potent PAR2 biased agonist. Selectively activates ERK1/2 signaling (EC50= 2 nM for ERK1/2 phosphorylation versus 80 nM for Ca2+release). Reduces cytoKi ne-induced caspase 3/8 activation, promotes scratch-wound healing, and induces IL-8 secretion, in human colorectal cancer (HT29) cellsin vitro. |
|---|---|
| References | 1. Jiang et al (2017) Biased signaling by agonists of protease activated receptor 2. ACS Chem.Biol. 12 1217 PMID: 28169521 |
| Molecular Formula | C30H49N9O6 |
|---|---|
| Molecular Weight | 631.779 |