AY 254
Modify Date: 2024-01-14 10:10:01
AY 254 structure
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Common Name | AY 254 | ||
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| CAS Number | 2093408-03-6 | Molecular Weight | 631.779 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H49N9O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AY 254AY 254 is a potent PAR2 biased agonist. Selectively activates ERK1/2 signaling (EC50= 2 nM for ERK1/2 phosphorylation versus 80 nM for Ca2+release). Reduces cytoKi ne-induced caspase 3/8 activation, promotes scratch-wound healing, and induces IL-8 secretion, in human colorectal cancer (HT29) cellsin vitro. |
| Name | AY 254 |
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| Description | AY 254 is a potent PAR2 biased agonist. Selectively activates ERK1/2 signaling (EC50= 2 nM for ERK1/2 phosphorylation versus 80 nM for Ca2+release). Reduces cytoKi ne-induced caspase 3/8 activation, promotes scratch-wound healing, and induces IL-8 secretion, in human colorectal cancer (HT29) cellsin vitro. |
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| References | 1. Jiang et al (2017) Biased signaling by agonists of protease activated receptor 2. ACS Chem.Biol. 12 1217 PMID: 28169521 |
| Molecular Formula | C30H49N9O6 |
|---|---|
| Molecular Weight | 631.779 |