480462-62-2
480462-62-2 structure
- Name: JTK-109
- Chemical Name: JTK-109
- CAS Number: 480462-62-2
- Molecular Formula: C37H33ClFN3O4
- Molecular Weight: 638.13
- Catalog: Signaling Pathways Metabolic Enzyme/Protease HCV Protease
- Create Date: 2023-11-12 11:34:14
- Modify Date: 2026-06-27 11:26:30
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JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.
| Name | JTK-109 |
|---|---|
| Synonyms |
JTK109
2-[4-[2-(4-Chlorophenyl)-5-(2-oxopyrrolidin-1-yl)benzyloxy]-2-fluorophenyl]-1-cyclohexylbenzimidazol 1H-Benzimidazole-5-cboxylic acid, 2-[4-[[4'-chloro-4-(2-oxo-1-pyrrolidinyl)[1,1'-biphenyl]-2-yl]methoxy]-2-fluorophenyl]-1-cyclohexyl JTK-109, 10 mM in DMSO |
| Description | JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes. |
|---|---|
| References | 1. Hirashima S, et al. Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109. J Med Chem. 2006 Jul 27;49(15):4721-36. |
| Molecular Formula | C37H33ClFN3O4 |
|---|---|
| Molecular Weight | 638.13 |