946400-19-7

946400-19-7 structure

Name: 3-chloro-4-[[(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-piperazinyl]sulfonyl]-Benzonitrile
Chemical Name: 3-chloro-4-[[(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-piperazinyl]sulfonyl]-Benzonitrile
CAS Number: 946400-19-7
Molecular Formula: C₁₉H₁₆ClF₄N₃O₂S
Molecular Weight: 461.86
Create Date: 2023-12-15 20:04:26
Modify Date: 2024-09-12 22:26:33
3-chloro-4-[[(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-piperazinyl]sulfonyl]-Benzonitrile shows inhibitory activities for hHSD1 and mHSD1 with IC50s of 16 nM and 10 nM.

Name	3-chloro-4-[[(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-piperazinyl]sulfonyl]-Benzonitrile

Description	3-chloro-4-[[(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-piperazinyl]sulfonyl]-Benzonitrile shows inhibitory activities for hHSD1 and mHSD1 with IC50s of 16 nM and 10 nM.
References	1. Wan ZK, et al. Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model. J Med Chem. 2009 Sep 10;52(17):5449-61.

Molecular Formula	C₁₉H₁₆ClF₄N₃O₂S
Molecular Weight	461.86