2241283-11-2

2241283-11-2 structure

Name: Anticancer agent 147
Chemical Name: Anticancer agent 147
CAS Number: 2241283-11-2
Molecular Formula: C₃₂H₄₀BrN₃O₂
Molecular Weight: 578.58
Catalog: Signaling Pathways Apoptosis Ferroptosis
Create Date: 2024-09-15 18:02:43
Modify Date: 2024-09-15 18:02:43
Anticancer agent 147 (compound 6j) is a derivative of sophoridine (HY-N1373) and is a ferroptosis inducer. Anticancer agent 147 can promote the accumulation of intracellular Fe2+, reactive oxygen species (ROS) and MDA, increase ER stress, and upregulate the expression of the activating transcription factor ATF3. Anticancer agent 147 has good anti-liver cancer effects in vitro and in vivo[1].

Name	Anticancer agent 147

Description	Anticancer agent 147 (compound 6j) is a derivative of sophoridine (HY-N1373) and is a ferroptosis inducer. Anticancer agent 147 can promote the accumulation of intracellular Fe2+, reactive oxygen species (ROS) and MDA, increase ER stress, and upregulate the expression of the activating transcription factor ATF3. Anticancer agent 147 has good anti-liver cancer effects in vitro and in vivo[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> Ferroptosis
References	[1]. Tian K, et al. Sophoridine derivative 6j inhibits liver cancer cell proliferation via ATF3 mediated ferroptosis. Cell Death Discov. 2023 Aug 14;9(1):296..

Molecular Formula	C₃₂H₄₀BrN₃O₂
Molecular Weight	578.58