1065581-69-2

1065581-69-2 structure

Name: CBP/p300-IN-21
Chemical Name: CBP/p300-IN-21
CAS Number: 1065581-69-2
Molecular Formula: C₁₉H₁₆ClNO₄
Molecular Weight: 357.79
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2024-09-08 12:28:50
Modify Date: 2024-09-08 12:28:50
CBP/p300-IN-21 (Compound 5d) is a selective CBP/p300 inhibitor (IC50: 0.07 and 1.755 μM for p300 and CBP). CBP/p300-IN-21 decreases H3K18Ac level. CBP/p300-IN-21 inhibits growth of 4T1 tumor growth in mice[1].

Name	CBP/p300-IN-21

Description	CBP/p300-IN-21 (Compound 5d) is a selective CBP/p300 inhibitor (IC50: 0.07 and 1.755 μM for p300 and CBP). CBP/p300-IN-21 decreases H3K18Ac level. CBP/p300-IN-21 inhibits growth of 4T1 tumor growth in mice[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Acetyltransferase Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	0.07 and 1.755 μM for p300 and CBP[1]
References	[1]. Zhong X, et al. Discovery of berberine analogs as potent and highly selective p300/CBP HAT inhibitors. Bioorg Chem. 2023 Sep;138:106597.

Molecular Formula	C₁₉H₁₆ClNO₄
Molecular Weight	357.79