2649154-82-3

2649154-82-3 structure

Name: CIAC001
Chemical Name: CIAC001
CAS Number: 2649154-82-3
Molecular Formula: C₂₀H₂₅N₃O₂
Molecular Weight: 339.43
Catalog: Research Areas Neurological Disease
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CIAC001 is a Pyruvate Kinase PKM2 inhibitor with anti-neuroinflammatory activity. CIAC001 inhibits LPS-induced proinflammatory nitric oxide (NO) production and protects immunologically active BV-2 cells (IC50=2.5 μM). CIAC001 also has anti-neuroinflammation in mouse models and inhibits chronic morphine-induced addiction[1].

Name	CIAC001

Description	CIAC001 is a Pyruvate Kinase PKM2 inhibitor with anti-neuroinflammatory activity. CIAC001 inhibits LPS-induced proinflammatory nitric oxide (NO) production and protects immunologically active BV-2 cells (IC50=2.5 μM). CIAC001 also has anti-neuroinflammation in mouse models and inhibits chronic morphine-induced addiction[1].
Related Catalog	Research Areas >> Neurological Disease
Target	PKM2[1]
References	[1]. Jin S, et al. Cannabidiol Analogue CIAC001 for the Treatment of Morphine-Induced Addiction by Targeting PKM2. J Med Chem. 2023 Aug 24;66(16):11498-11516.

Molecular Formula	C₂₀H₂₅N₃O₂
Molecular Weight	339.43