2832865-25-3

2832865-25-3 structure

Name: ERD-3111
Chemical Name: ERD-3111
CAS Number: 2832865-25-3
Molecular Formula: C₄₅H₄₆F₄N₈O₅
Molecular Weight: 854.89
Catalog: Signaling Pathways PROTAC PROTAC
Create Date: 2023-12-05 15:39:27
Modify Date: 2024-01-20 10:29:27
ERD-3111 (Compound 44) is an orally active PROTAC ERα degrader (DC50: 0.5 nM). ERD-3111 inhibits tumor growth in the parental MCF-7 xenograft model with wild-type ER and two clinically relevant ESR1 mutated mice model. ERD-3111 can be used in the research of ER+ breast cancer[1].

Name	ERD-3111

Description	ERD-3111 (Compound 44) is an orally active PROTAC ERα degrader (DC50: 0.5 nM). ERD-3111 inhibits tumor growth in the parental MCF-7 xenograft model with wild-type ER and two clinically relevant ESR1 mutated mice model. ERD-3111 can be used in the research of ER+ breast cancer[1].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC
Target	ERα[1]
References	[1]. Chen Z, et al. Discovery of ERD-3111 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader with Strong Antitumor Activity. J Med Chem. 2023 Aug 30.

Molecular Formula	C₄₅H₄₆F₄N₈O₅
Molecular Weight	854.89