ERD-3111

Modify Date: 2024-01-20 10:29:27

ERD-3111 structure	Common Name	ERD-3111
	CAS Number	2832865-25-3	Molecular Weight	854.89
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₅H₄₆F₄N₈O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ERD-3111

ERD-3111 (Compound 44) is an orally active PROTAC ERα degrader (DC50: 0.5 nM). ERD-3111 inhibits tumor growth in the parental MCF-7 xenograft model with wild-type ER and two clinically relevant ESR1 mutated mice model. ERD-3111 can be used in the research of ER+ breast cancer[1].

Name	ERD-3111

Description	ERD-3111 (Compound 44) is an orally active PROTAC ERα degrader (DC50: 0.5 nM). ERD-3111 inhibits tumor growth in the parental MCF-7 xenograft model with wild-type ER and two clinically relevant ESR1 mutated mice model. ERD-3111 can be used in the research of ER+ breast cancer[1].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC
Target	ERα[1]
References	[1]. Chen Z, et al. Discovery of ERD-3111 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader with Strong Antitumor Activity. J Med Chem. 2023 Aug 30.

Molecular Formula	C₄₅H₄₆F₄N₈O₅
Molecular Weight	854.89

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ERD-3111

Use of ERD-3111

Names

ERD-3111 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.