2413262-74-3

2413262-74-3 structure

Name: GB-6
Chemical Name: GB-6
CAS Number: 2413262-74-3
Molecular Formula: C₃₂H₄₅N₁₁O₈
Molecular Weight: 711.77
Catalog: Signaling Pathways GPCR/G Protein Bombesin Receptor
Create Date: 2023-10-30 18:04:14
Modify Date: 2025-08-25 06:36:56
GB-6 is a short linear peptide that targets the gastrin releasing peptide receptor (GRPR). GRPR is overexpressed in pancreatic cancer. Based on the tumor selectivity and tumor-specific accumulation properties of GB-6, GB-6 labeled with near infrared (NIR) fluorescent dyes or radionuclide netium-99m (99mTc) can be used as a high-contrast imaging probe. GB-6 has excellent in vivo stability, with tumor to pancreatic and intestinal fluorescence signal ratios of 5.2 and 6.3, respectively, in SW199 0 subcutaneous xenograft models. GB-6 can rapidly target tumors and accurately delineate tumor boundaries, which has broad application prospects[1].

Name	GB-6

Description	GB-6 is a short linear peptide that targets the gastrin releasing peptide receptor (GRPR). GRPR is overexpressed in pancreatic cancer. Based on the tumor selectivity and tumor-specific accumulation properties of GB-6, GB-6 labeled with near infrared (NIR) fluorescent dyes or radionuclide netium-99m (99mTc) can be used as a high-contrast imaging probe. GB-6 has excellent in vivo stability, with tumor to pancreatic and intestinal fluorescence signal ratios of 5.2 and 6.3, respectively, in SW199 0 subcutaneous xenograft models. GB-6 can rapidly target tumors and accurately delineate tumor boundaries, which has broad application prospects[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Bombesin Receptor
Target	Gastrin releasing peptide receptor (GRPR)[1]
References	[1]. Tu Y, et al. Novel GRPR-Targeting Peptide for Pancreatic Cancer Molecular Imaging in Orthotopic and Liver Metastasis Mouse Models. Anal Chem. 2023 Aug 1;95(30):11429-11439.

Molecular Formula	C₃₂H₄₅N₁₁O₈
Molecular Weight	711.77