GB-6

Modify Date: 2025-08-25 06:36:56

GB-6 Structure
GB-6 structure
 Common Name GB-6
CAS Number 2413262-74-3 Molecular Weight 711.77
Density N/A Boiling Point N/A
Molecular Formula C32H45N11O8 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of GB-6


GB-6 is a short linear peptide that targets the gastrin releasing peptide receptor (GRPR). GRPR is overexpressed in pancreatic cancer. Based on the tumor selectivity and tumor-specific accumulation properties of GB-6, GB-6 labeled with near infrared (NIR) fluorescent dyes or radionuclide netium-99m (99mTc) can be used as a high-contrast imaging probe. GB-6 has excellent in vivo stability, with tumor to pancreatic and intestinal fluorescence signal ratios of 5.2 and 6.3, respectively, in SW199 0 subcutaneous xenograft models. GB-6 can rapidly target tumors and accurately delineate tumor boundaries, which has broad application prospects[1].

 Names

Name GB-6

 GB-6 Biological Activity

Description GB-6 is a short linear peptide that targets the gastrin releasing peptide receptor (GRPR). GRPR is overexpressed in pancreatic cancer. Based on the tumor selectivity and tumor-specific accumulation properties of GB-6, GB-6 labeled with near infrared (NIR) fluorescent dyes or radionuclide netium-99m (99mTc) can be used as a high-contrast imaging probe. GB-6 has excellent in vivo stability, with tumor to pancreatic and intestinal fluorescence signal ratios of 5.2 and 6.3, respectively, in SW199 0 subcutaneous xenograft models. GB-6 can rapidly target tumors and accurately delineate tumor boundaries, which has broad application prospects[1].
Related Catalog
Target

Gastrin releasing peptide receptor (GRPR)[1]

References

[1]. Tu Y, et al. Novel GRPR-Targeting Peptide for Pancreatic Cancer Molecular Imaging in Orthotopic and Liver Metastasis Mouse Models. Anal Chem. 2023 Aug 1;95(30):11429-11439.  

 Chemical & Physical Properties

Molecular Formula C32H45N11O8
Molecular Weight 711.77
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Chemsrc provides GB-6(CAS#:2413262-74-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of GB-6 are included as well.>> amp version: GB-6

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