2860554-32-9

2860554-32-9 structure

Name: Sigma-2 Radioligand 1
Chemical Name: Sigma-2 Radioligand 1
CAS Number: 2860554-32-9
Molecular Formula: C₂₄H₃₀FN₃O₃
Molecular Weight: 427.51
Catalog: Signaling Pathways GPCR/G Protein Sigma Receptor
Create Date: 2023-11-04 11:30:44
Modify Date: 2025-09-14 22:05:21
Sigma-2 Radioligand 1 (compound 1) is a Sigma-2 selective ligand. Sigma-2 Radioligand 1 has good biodistribution in mice and good in vivo activity in rats. [18F] Modified Sigma-2 Radioligand 1 for visualization of tumors in micro-PET/CT imaging, exhibiting high tumor uptake and tumor-to-background ratio. Experiments show that Sigma-2 Radioligand 1 binds highly specifically in U87MG glioma xenografts[1].

Name	Sigma-2 Radioligand 1

Description	Sigma-2 Radioligand 1 (compound 1) is a Sigma-2 selective ligand. Sigma-2 Radioligand 1 has good biodistribution in mice and good in vivo activity in rats. [18F] Modified Sigma-2 Radioligand 1 for visualization of tumors in micro-PET/CT imaging, exhibiting high tumor uptake and tumor-to-background ratio. Experiments show that Sigma-2 Radioligand 1 binds highly specifically in U87MG glioma xenografts[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Sigma Receptor
Target	Ki: 2.57 nM (Sigma-2, σ2)[1]
References	[1]. Wang T, et al. Development of a Highly Specific 18F-Labeled Radioligand for Imaging of the Sigma-2 Receptor in Brain Tumors. J Med Chem. 2023 Sep 13.. .

Molecular Formula	C₂₄H₃₀FN₃O₃
Molecular Weight	427.51