Sigma-2 Radioligand 1

Modify Date: 2024-01-13 20:43:51

Sigma-2 Radioligand 1 Structure
Sigma-2 Radioligand 1 structure
 Common Name Sigma-2 Radioligand 1
CAS Number 2860554-32-9 Molecular Weight 427.51
Density N/A Boiling Point N/A
Molecular Formula C24H30FN3O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Sigma-2 Radioligand 1


Sigma-2 Radioligand 1 (compound 1) is a Sigma-2 selective ligand. Sigma-2 Radioligand 1 has good biodistribution in mice and good in vivo activity in rats. [18F] Modified Sigma-2 Radioligand 1 for visualization of tumors in micro-PET/CT imaging, exhibiting high tumor uptake and tumor-to-background ratio. Experiments show that Sigma-2 Radioligand 1 binds highly specifically in U87MG glioma xenografts[1].

 Names

Name Sigma-2 Radioligand 1

 Sigma-2 Radioligand 1 Biological Activity

Description Sigma-2 Radioligand 1 (compound 1) is a Sigma-2 selective ligand. Sigma-2 Radioligand 1 has good biodistribution in mice and good in vivo activity in rats. [18F] Modified Sigma-2 Radioligand 1 for visualization of tumors in micro-PET/CT imaging, exhibiting high tumor uptake and tumor-to-background ratio. Experiments show that Sigma-2 Radioligand 1 binds highly specifically in U87MG glioma xenografts[1].
Related Catalog
Target

Ki: 2.57 nM (Sigma-2, σ2)[1]

References

[1]. Wang T, et al. Development of a Highly Specific 18F-Labeled Radioligand for Imaging of the Sigma-2 Receptor in Brain Tumors. J Med Chem. 2023 Sep 13.. .  

 Chemical & Physical Properties

Molecular Formula C24H30FN3O3
Molecular Weight 427.51
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Chemsrc provides Sigma-2 Radioligand 1(CAS#:2860554-32-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Sigma-2 Radioligand 1 are included as well.>> amp version: Sigma-2 Radioligand 1

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