2922115-32-8

2922115-32-8 structure

Name: SWS1
Chemical Name: SWS1
CAS Number: 2922115-32-8
Molecular Formula: C₄₇H₅₃ClN₆O₅S
Molecular Weight: 849.48
Catalog: Signaling Pathways Immunology/Inflammation PD-1/PD-L1
Create Date: 2023-11-05 15:07:28
Modify Date: 2024-01-14 10:48:44
SWS1 is a d-(+)-biotin-conjugated PD-L1 inhibitor (IC50: 1.8 nM) with anticancer activity. SWS1 can increase the number of tumor-infiltrating lymphocytes and exhibit anti-tumor efficacy in the B16-F10 mouse model (TGI=66.1%)[1].

Name	SWS1

Description	SWS1 is a d-(+)-biotin-conjugated PD-L1 inhibitor (IC50: 1.8 nM) with anticancer activity. SWS1 can increase the number of tumor-infiltrating lymphocytes and exhibit anti-tumor efficacy in the B16-F10 mouse model (TGI=66.1%)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Signaling Pathways >> Immunology/Inflammation >> PD-1/PD-L1
Target	IC50: 1.8 nM (PD-1/PD-L1)[1]
References	[1]. Ding Z, et al. Discovery of Novel d-(+)-Biotin-Conjugated Resorcinol Dibenzyl Ether-Based PD-L1 Inhibitors for Targeted Cancer Immunotherapy. J Med Chem. 2023 Aug 10;66(15):10364-10380..

Molecular Formula	C₄₇H₅₃ClN₆O₅S
Molecular Weight	849.48