SWS1

Modify Date: 2024-01-14 10:48:44

SWS1 structure	Common Name	SWS1
	CAS Number	2922115-32-8	Molecular Weight	849.48
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₇H₅₃ClN₆O₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SWS1

SWS1 is a d-(+)-biotin-conjugated PD-L1 inhibitor (IC50: 1.8 nM) with anticancer activity. SWS1 can increase the number of tumor-infiltrating lymphocytes and exhibit anti-tumor efficacy in the B16-F10 mouse model (TGI=66.1%)[1].

Name	SWS1

Description	SWS1 is a d-(+)-biotin-conjugated PD-L1 inhibitor (IC50: 1.8 nM) with anticancer activity. SWS1 can increase the number of tumor-infiltrating lymphocytes and exhibit anti-tumor efficacy in the B16-F10 mouse model (TGI=66.1%)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Signaling Pathways >> Immunology/Inflammation >> PD-1/PD-L1
Target	IC50: 1.8 nM (PD-1/PD-L1)[1]
References	[1]. Ding Z, et al. Discovery of Novel d-(+)-Biotin-Conjugated Resorcinol Dibenzyl Ether-Based PD-L1 Inhibitors for Targeted Cancer Immunotherapy. J Med Chem. 2023 Aug 10;66(15):10364-10380..

Molecular Formula	C₄₇H₅₃ClN₆O₅S
Molecular Weight	849.48

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SWS1

Use of SWS1

Names

SWS1 Biological Activity

Chemical & Physical Properties