2849471-75-4

2849471-75-4 structure

Name: WLB-89462
Chemical Name: WLB-89462
CAS Number: 2849471-75-4
Molecular Formula: C₂₁H₂₉N₅O₃
Molecular Weight: 399.49
Catalog: Signaling Pathways GPCR/G Protein Sigma Receptor
Create Date: 2024-09-23 13:16:23
Modify Date: 2024-09-23 13:16:23
WLB-89462 (Compound 20c) is a selective σ2 receptor ligand (Ki: 13 nM). WLB-89462 has neuroprotective activity. WLB-89462 improves short-term memory impairment induced by Aβ peptide in rats. WLB-89462 has good ADMET profile (good solubility, no CYP inhibition, good metabolic stability, high permeability, brain penetration, and high oral exposure in rodents)[1].

Name	WLB-89462

Description	WLB-89462 (Compound 20c) is a selective σ2 receptor ligand (Ki: 13 nM). WLB-89462 has neuroprotective activity. WLB-89462 improves short-term memory impairment induced by Aβ peptide in rats. WLB-89462 has good ADMET profile (good solubility, no CYP inhibition, good metabolic stability, high permeability, brain penetration, and high oral exposure in rodents)[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Sigma Receptor
Target	Ki: 13 nM (σ2 receptor)[1]
References	[1]. Christmann U, et al. Discovery of WLB-89462, a New Drug-like and Highly Selective σ2 Receptor Ligand with Neuroprotective Properties. J Med Chem. 2023 Sep 14;66(17):12499-12519.

Molecular Formula	C₂₁H₂₉N₅O₃
Molecular Weight	399.49