WLB-89462

Modify Date: 2026-07-16 23:02:34

WLB-89462 structure	Common Name	WLB-89462
	CAS Number	2849471-75-4	Molecular Weight	399.49
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₂₉N₅O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of WLB-89462

WLB-89462 (Compound 20c) is a selective σ2 receptor ligand (Ki: 13 nM). WLB-89462 has neuroprotective activity. WLB-89462 improves short-term memory impairment induced by Aβ peptide in rats. WLB-89462 has good ADMET profile (good solubility, no CYP inhibition, good metabolic stability, high permeability, brain penetration, and high oral exposure in rodents)[1].

Name	WLB-89462

Description	WLB-89462 (Compound 20c) is a selective σ2 receptor ligand (Ki: 13 nM). WLB-89462 has neuroprotective activity. WLB-89462 improves short-term memory impairment induced by Aβ peptide in rats. WLB-89462 has good ADMET profile (good solubility, no CYP inhibition, good metabolic stability, high permeability, brain penetration, and high oral exposure in rodents)[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Sigma Receptor
Target	Ki: 13 nM (σ2 receptor)[1]
References	[1]. Christmann U, et al. Discovery of WLB-89462, a New Drug-like and Highly Selective σ2 Receptor Ligand with Neuroprotective Properties. J Med Chem. 2023 Sep 14;66(17):12499-12519.

Molecular Formula	C₂₁H₂₉N₅O₃
Molecular Weight	399.49
InChIKey	HPBOMWKBZHYYGE-UHFFFAOYSA-N
SMILES	CCc1ncc(-c2cc(C)no2)c(C2CCN(CC(=O)N3CCOCC3)CC2)n1

Name: Metabolic stability in human liver microsome assessed as parent compound remaining at...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5324505

Name: Metabolic stability in rat liver microsome assessed as parent compound remaining at 1...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5324506

Name: Selectivity ratio of Ki for displacement of [3H]-(+)-pentazocine from human sigma1 re...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5324503

Name: Displacement of [3H]-1,3-di-O-tolylguanidine from human sigma 2 receptor/TMEM97 trans...
Source: ChEMBL
Target: Sigma intracellular receptor 2
External Id: CHEMBL5324504

Name: Displacement of [3H]-(+)-pentazocine from human sigma1 receptor transfected in HEK293...
Source: ChEMBL
Target: Sigma non-opioid intracellular receptor 1
External Id: CHEMBL5324502

Name: Neuroprotective activity against MPP+ induced rat neurons at 10 uM pretreated with co...
Source: ChEMBL
Target: Neuron
External Id: CHEMBL5324535

Name: Anti-alzheimer activity against amyloid beta peptide-induced cognitive impairment in ...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL5324536

Name: Ratio AUC in Wistar rat brain to plasma at 10 mg/kg, po measured for 10 mins by UPLC-...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5324533

Name: Drug concentration in Wistar rat plasma at 10 mg/kg, po measured for 10 mins by UPLC-...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5324534

Name: Volume of distribution at steady state in Wistar rat at 1 mg/kg, iv by UPLC-MS/MS ana...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5324531

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: WLB-89462
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Purity: 98.0%
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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.