WLB-89462

Modify Date: 2024-09-23 13:16:23

WLB-89462 Structure
WLB-89462 structure
Common Name WLB-89462
CAS Number 2849471-75-4 Molecular Weight 399.49
Density N/A Boiling Point N/A
Molecular Formula C21H29N5O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of WLB-89462


WLB-89462 (Compound 20c) is a selective σ2 receptor ligand (Ki: 13 nM). WLB-89462 has neuroprotective activity. WLB-89462 improves short-term memory impairment induced by Aβ peptide in rats. WLB-89462 has good ADMET profile (good solubility, no CYP inhibition, good metabolic stability, high permeability, brain penetration, and high oral exposure in rodents)[1].

 Names

Name WLB-89462

 WLB-89462 Biological Activity

Description WLB-89462 (Compound 20c) is a selective σ2 receptor ligand (Ki: 13 nM). WLB-89462 has neuroprotective activity. WLB-89462 improves short-term memory impairment induced by Aβ peptide in rats. WLB-89462 has good ADMET profile (good solubility, no CYP inhibition, good metabolic stability, high permeability, brain penetration, and high oral exposure in rodents)[1].
Related Catalog
Target

Ki: 13 nM (σ2 receptor)[1]

References

[1]. Christmann U, et al. Discovery of WLB-89462, a New Drug-like and Highly Selective σ2 Receptor Ligand with Neuroprotective Properties. J Med Chem. 2023 Sep 14;66(17):12499-12519.  

 Chemical & Physical Properties

Molecular Formula C21H29N5O3
Molecular Weight 399.49