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2894832-05-2

2894832-05-2 structure

2894832-05-2 structure

Name: WM-586
Chemical Name: WM-586
CAS Number: 2894832-05-2
Molecular Formula: C₂₀H₂₀F₃N₅O₃S
Molecular Weight: 467.46
Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
Create Date: 2024-09-27 20:53:17
Modify Date: 2025-08-26 08:54:09
WM-586 is a covalent WDR5 inhibitor that disrupts the binding of WDR5 to MYC. WM-586 specifically decreases cellular WDR5 and MYC interaction with the IC50 of 101 nM in HTRF assay[1].

Name	WM-586

Description	WM-586 is a covalent WDR5 inhibitor that disrupts the binding of WDR5 to MYC. WM-586 specifically decreases cellular WDR5 and MYC interaction with the IC50 of 101 nM in HTRF assay[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Methyltransferase
Target	IC50: 101 nM (WDR5 and MYC interaction)[1]
References	[1]. Ding J, et al. Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction. ACS Chem Biol. 2023 Jan 20;18(1):34-40.

Molecular Formula	C₂₀H₂₀F₃N₅O₃S
Molecular Weight	467.46

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