2010167-25-4

2010167-25-4 structure
2010167-25-4 structure
  • Name: αO-Conotoxin GeXIVA
  • Chemical Name: αO-Conotoxin GeXIVA
  • CAS Number: 2010167-25-4
  • Molecular Formula: C139H227N55O41S4
  • Molecular Weight: 3452.89
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
  • Create Date: 2024-04-08 10:44:13
  • Modify Date: 2024-04-08 10:44:13
  • αO-Conotoxin GeXIVA is a potent α9α10 nAChR antagonist with an IC50 of 12 nM against rat α9α10. αO-Conotoxin GeXIVA shows analgesic in animal models of pain[1].

Name αO-Conotoxin GeXIVA
Description αO-Conotoxin GeXIVA is a potent α9α10 nAChR antagonist with an IC50 of 12 nM against rat α9α10. αO-Conotoxin GeXIVA shows analgesic in animal models of pain[1].
Related Catalog
Target

IC50: 12 nM (rat α9α10), 52 nM (human α9α10), 520 nM (mouse α1β1δε), 660 nM (rat α7), 940 nM (rat α3β2), 1380 nM (rat α6/α3β4), 1610 nM (rat α2β2), 6930 nM (rat α3β4)[1]

References

[1]. Xu P, et al. Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA. J Med Chem. 2020 Feb 27;63(4):1564-1575.  

Molecular Formula C139H227N55O41S4
Molecular Weight 3452.89