αO-Conotoxin GeXIVA

Modify Date: 2025-09-11 22:54:29

αO-Conotoxin GeXIVA structure	Common Name	αO-Conotoxin GeXIVA
	CAS Number	2010167-25-4	Molecular Weight	3452.89
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₃₉H₂₂₇N₅₅O₄₁S₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of αO-Conotoxin GeXIVA

αO-Conotoxin GeXIVA is a potent α9α10 nAChR antagonist with an IC50 of 12 nM against rat α9α10. αO-Conotoxin GeXIVA shows analgesic in animal models of pain[1].

Name	αO-Conotoxin GeXIVA

Description	αO-Conotoxin GeXIVA is a potent α9α10 nAChR antagonist with an IC50 of 12 nM against rat α9α10. αO-Conotoxin GeXIVA shows analgesic in animal models of pain[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
Target	IC50: 12 nM (rat α9α10), 52 nM (human α9α10), 520 nM (mouse α1β1δε), 660 nM (rat α7), 940 nM (rat α3β2), 1380 nM (rat α6/α3β4), 1610 nM (rat α2β2), 6930 nM (rat α3β4)[1]
References	[1]. Xu P, et al. Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA. J Med Chem. 2020 Feb 27;63(4):1564-1575.

Molecular Formula	C₁₃₉H₂₂₇N₅₅O₄₁S₄
Molecular Weight	3452.89

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