261766-32-9
261766-32-9 structure
- Name: N-(2-Phenylethyl)indomethacin Amide
- Chemical Name: N-(2-Phenylethyl)indomethacin Amide
- CAS Number: 261766-32-9
- Molecular Formula: C27H25ClN2O3
- Molecular Weight: 460.95
- Catalog: Signaling Pathways Immunology/Inflammation COX
- Create Date: 2018-11-28 16:49:15
- Modify Date: 2024-01-03 18:00:23
-
LM-4108 (N-(2-Phenylethyl)-indomethacin amide) is a selective and orally active COX-2 inhibitor with an IC50 of 0.06 μM for purified human COX-2. LM-4108 shows anti-inflammatory activity and may be effective in prevention of cancer. Half-lives for the disappearance of 10 μM LM-4108 in rat, human, and mouse liver microsomes were 11 min, 21 min, and 51 min, respectively[1].
| Name | N-(2-Phenylethyl)indomethacin Amide |
|---|---|
| Synonyms |
2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-N-(2-phenylethyl)acetamide
2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-(2-phenylethyl)acetamide 1H-Indole-3-acetamide, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-N-(2-phenylethyl)- |
| Description | LM-4108 (N-(2-Phenylethyl)-indomethacin amide) is a selective and orally active COX-2 inhibitor with an IC50 of 0.06 μM for purified human COX-2. LM-4108 shows anti-inflammatory activity and may be effective in prevention of cancer. Half-lives for the disappearance of 10 μM LM-4108 in rat, human, and mouse liver microsomes were 11 min, 21 min, and 51 min, respectively[1]. |
|---|---|
| Related Catalog | |
| Target |
Human COX-2:60 nM (IC50) Ovine COX-1:>66 μM (IC50) |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 640.5±55.0 °C at 760 mmHg |
| Molecular Formula | C27H25ClN2O3 |
| Molecular Weight | 460.95 |
| Flash Point | 341.2±31.5 °C |
| Exact Mass | 460.155365 |
| PSA | 63.82000 |
| LogP | 4.31 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.613 |
