564-13-6

564-13-6 structure
564-13-6 structure
  • Name: Terminolic acid
  • Chemical Name: (4aS,6aR,6aS,6bR,8R,9R,10R,11R,12aR,14bR)-8,10,11-trihydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
  • CAS Number: 564-13-6
  • Molecular Formula: C30H48O6
  • Molecular Weight: 504.69900
  • Catalog: Signaling Pathways Anti-infection Bacterial
  • Create Date: 2017-02-22 19:04:10
  • Modify Date: 2025-08-25 12:27:49
  • Terminolic acid is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum. Terminolic acid can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL-1β and IL-6, and enhance anti-inflammatory cytokines by binding to IL-4 receptor binding sites. Terminolic acid also exhibits moderate antibacterial activity[1][1].

Name (4aS,6aR,6aS,6bR,8R,9R,10R,11R,12aR,14bR)-8,10,11-trihydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
Synonyms Olean-12-en-28-oic acid,2,3,6,23-tetrahydroxy-,(2alpha,3beta,4alpha,6beta)
2,3,6,23-Tetrahydroxyolean-12-en-28-oic acid (2alpha,3beta,4alpha,6beta)
Terminolic acid
Description Terminolic acid is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum. Terminolic acid can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL-1β and IL-6, and enhance anti-inflammatory cytokines by binding to IL-4 receptor binding sites. Terminolic acid also exhibits moderate antibacterial activity[1][1].
Related Catalog
References

[1]. Gossan DPA, et, al. Antibacterial and cytotoxic triterpenoids from the roots of Combretum racemosum. Fitoterapia. 2016 Apr;110:89-95.

[2]. Legiawati L, et, al. In silico study of Centella asiatica active compounds as anti-inflammatory agent by decreasing Il-1 and Il-6 activity, promoting Il-4 activity. /J. Pharm. Sci. & Res. Vol. 10(9), 2018, 2142-2147.

Molecular Formula C30H48O6
Molecular Weight 504.69900
Exact Mass 504.34500
PSA 118.22000
LogP 4.14760
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