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1683534-97-5

1683534-97-5 structure

1683534-97-5 structure

Name: (1S)-CCR2 antagonist 1
Chemical Name: (1S)-CCR2 antagonist 1
CAS Number: 1683534-97-5
Molecular Formula: C₂₈H₃₂BrF₃N₂O
Molecular Weight: 549.47
Catalog: Signaling Pathways GPCR/G Protein CCR
Create Date: 2024-01-08 16:40:07
Modify Date: 2024-01-08 16:40:07
(1S)-CCR2 antagonist 1 is a left-handed chiral body of CCR2 antagonist 1 (HY-112792). CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM[1].

Name	(1S)-CCR2 antagonist 1

Description	(1S)-CCR2 antagonist 1 is a left-handed chiral body of CCR2 antagonist 1 (HY-112792). CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CCR Research Areas >> Endocrinology Signaling Pathways >> Immunology/Inflammation >> CCR
In Vitro	The combination of SAR and SKR in the hit-to-lead process results in the discovery of a new higheaffinity and longeresidenceetime CCR2 antagonist (CCR2 antagonist 1 (compound 15a), Ki=2.4 nM; RT=714 min)[1].
References	[1]. Vilums M, et al. When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists. Eur J Med Chem. 2015 Mar 26;93:121-34.

Molecular Formula	C₂₈H₃₂BrF₃N₂O
Molecular Weight	549.47

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