2635328-79-7

2635328-79-7 structure

Name: JDB175
Chemical Name: JDB175
CAS Number: 2635328-79-7
Molecular Formula: C₂₆H₂₁F₃N₄O₂
Molecular Weight: 478.47
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2024-01-12 16:44:36
Modify Date: 2024-01-12 16:44:36
JDB175 is a highly selective BTK inhibitor with oral activity and excellent blood-brain barrier penetration. JDB175 shows good activity in the mouse model of central nervous system lymphoma without obvious signs of toxicity, effectively inhibits the proliferation of BTK signaling pathway of human lymphoma cells, induces cell cycle arrest, and promotes cell apoptosis [1].

Name	JDB175

Description	JDB175 is a highly selective BTK inhibitor with oral activity and excellent blood-brain barrier penetration. JDB175 shows good activity in the mouse model of central nervous system lymphoma without obvious signs of toxicity, effectively inhibits the proliferation of BTK signaling pathway of human lymphoma cells, induces cell cycle arrest, and promotes cell apoptosis [1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk
References	[1]. Xia Y, et al. A novel Bruton's tyrosine kinase inhibitor JDB175 shows potent efficacy to suppress central nervous system lymphoma. MedComm (2020). 2023 Nov 4;4(6):e424.

Molecular Formula	C₂₆H₂₁F₃N₄O₂
Molecular Weight	478.47