2660230-90-8

2660230-90-8 structure

Name: NLRP3-IN-25
Chemical Name: NLRP3-IN-25
CAS Number: 2660230-90-8
Molecular Formula: C₁₇H₁₉F₃N₄O₅S
Molecular Weight: 448.42
Catalog: Signaling Pathways Immunology/Inflammation Interleukin Related
Create Date: 2023-12-21 19:08:01
Modify Date: 2024-03-08 11:18:21
NLRP3-IN-25 (compound 32) is an orally available NLRP3 inhibitor with anti-inflammatory activity. NLRP3-IN-25 attenuates renal injury in doxorubicin-induced glomerulonephritis in mice. NLRP3-IN-25 inhibits IL-1β secretion in THP-1 cells with an IC50 of 21 nM[1].

Name	NLRP3-IN-25

Description	NLRP3-IN-25 (compound 32) is an orally available NLRP3 inhibitor with anti-inflammatory activity. NLRP3-IN-25 attenuates renal injury in doxorubicin-induced glomerulonephritis in mice. NLRP3-IN-25 inhibits IL-1β secretion in THP-1 cells with an IC50 of 21 nM[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR) Research Areas >> Inflammation/Immunology
References	[1]. Ohba Y et al. Discovery of Novel NLRP3 Inflammasome Inhibitors Composed of an Oxazole Scaffold Bearing an Acylsulfamide[J]. ACS Medicinal Chemistry Letters, 2023.

Molecular Formula	C₁₇H₁₉F₃N₄O₅S
Molecular Weight	448.42