1585246-23-6

1585246-23-6 structure

Name: ON 108600
Chemical Name: ON 108600
CAS Number: 1585246-23-6
Molecular Formula: C₂₂H₁₄Cl₂N₂O₆S₂
Molecular Weight: 537.39
Catalog: Signaling Pathways Cell Cycle/DNA Damage Casein Kinase
Create Date: 2023-12-30 17:50:10
Modify Date: 2024-02-01 11:35:59
ON 108600 is a inhibitor for CK2 (Casein Kinase2)/TNIK/DYRK1 , with the IC50s for DYRK1A/DYRKB, DYRK2, CK2α1/CK2α2, and TNIK of 0.016 μm/0.007 μM, 0.028 μM, 0.05 μM/0.005 μM, and 0.005 μM, respectively. ON 108600 has antitumor activity[1].

Name	ON 108600

Description	ON 108600 is a inhibitor for CK2 (Casein Kinase2)/TNIK/DYRK1 , with the IC50s for DYRK1A/DYRKB, DYRK2, CK2α1/CK2α2, and TNIK of 0.016 μm/0.007 μM, 0.028 μM, 0.05 μM/0.005 μM, and 0.005 μM, respectively. ON 108600 has antitumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK Signaling Pathways >> Cell Cycle/DNA Damage >> Casein Kinase Signaling Pathways >> Stem Cell/Wnt >> Casein Kinase
Target	DYRK2:0.028 μM (IC50) DYRK1A:0.016 μM (IC50) DYRK1B:0.007 μM (IC50) CK2α2:0.005 μM (IC50) CK2α1:0.05 μM (IC50)
References	[1]. Katsutoshi Sato, et al. Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease. Nat Commun. 2021 Aug 3;12(1):4671.

Molecular Formula	C₂₂H₁₄Cl₂N₂O₆S₂
Molecular Weight	537.39