2935964-93-3

2935964-93-3 structure

Name: (S)-TNG260
Chemical Name: (S)-TNG260
CAS Number: 2935964-93-3
Molecular Formula: C₂₀H₁₈FN₃O₂S
Molecular Weight: 383.44
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2024-01-01 06:21:54
Modify Date: 2024-01-01 06:21:54
(S)-TNG260 is an isomer of TNG260 (HY-153358). TNG260 is a CoREST selective deacetylase (CoreDAC) inhibitor. TNG260 inhibits HDAC1 with 10-fold selectivity over HDAC3. TNG260 causes HDAC1 inhibition and reverses anti-PD1 resistance driven by STK11 deletion. TNG260 reduces intratumoral infiltration of neutrophils. TNG260 exhibits immune-mediated cell killing.

Name	(S)-TNG260

Description	(S)-TNG260 is an isomer of TNG260 (HY-153358). TNG260 is a CoREST selective deacetylase (CoreDAC) inhibitor. TNG260 inhibits HDAC1 with 10-fold selectivity over HDAC3. TNG260 causes HDAC1 inhibition and reverses anti-PD1 resistance driven by STK11 deletion. TNG260 reduces intratumoral infiltration of neutrophils. TNG260 exhibits immune-mediated cell killing.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
References	[1]. Ahronian L, et al. TNG260, a CoREST-selective deacetylase inhibitor, reverses anti-PD1 resistance driven by loss of STK11[J]. J Immunother, 2022, 10(2): A1-A1595.

Molecular Formula	C₂₀H₁₈FN₃O₂S
Molecular Weight	383.44