2415989-91-0

2415989-91-0 structure

2415989-91-0 structure

Name: SHP2-IN-23
Chemical Name: SHP2-IN-23
CAS Number: 2415989-91-0
Molecular Formula: C₂₄H₂₃ClN₈S
Molecular Weight: 491.01
Catalog: Signaling Pathways MAPK/ERK Pathway ERK
Create Date: 2024-01-17 16:57:19
Modify Date: 2024-01-17 16:57:19
SHP2-IN-23 (compound 30) is an orally active SHP2 inhibitor (IC50=38 nM) with excellent in vivo efficacy and pharmacokinetic profiles. SHP2-IN-23 inhibits ERK phosphorylation with IC50=5 nM[1].

Name	SHP2-IN-23

Description	SHP2-IN-23 (compound 30) is an orally active SHP2 inhibitor (IC50=38 nM) with excellent in vivo efficacy and pharmacokinetic profiles. SHP2-IN-23 inhibits ERK phosphorylation with IC50=5 nM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	IC50: 38 nM (SHP2), 5 nM (pERK)[1]
References	[1]. Elsayed M S A et al. Discovery of 5-Azaquinoxaline Derivatives as Potent and Orally Bioavailable Allosteric SHP2 Inhibitors[J]. ACS Medicinal Chemistry Letters, 2023.

Molecular Formula	C₂₄H₂₃ClN₈S
Molecular Weight	491.01